NpgRJ_ng_1616 937..944
نویسندگان
چکیده
The presence of low-copy-number regulators and switch-like signal propagation in regulatory networks are expected to increase noise in cellular processes. We developed a noise amplifier that detects fluctuations in the level of low-abundance mRNAs in yeast. The observed fluctuations are not due to the low number of molecules expressed from a gene per se but originate in the random, rare events of gene activation. The frequency of these events and the correlation between stochastic expressions of genes in a single cell depend on the positioning of the genes along the chromosomes. Transcriptional regulators produced by such random expression propagate noise to their target genes.
منابع مشابه
Corrigendum to “Development and psychometric analysis of the Duchenne muscular dystrophy Functional Ability Self-Assessment Tool (DMDSAT)” [Neuromuscular Disorders 25 (2015) 937–944]
Corrigendum to “Development and psychometric analysis of the Duchenne muscular dystrophy Functional Ability Self-Assessment Tool (DMDSAT)” [Neuromuscular Disorders 25 (2015) 937–944] Erik Landfeldt *, Anna Mayhew , Michelle Eagle , Peter Lindgren , Christopher F. Bell , Michela Guglieri , Volker Straub , Hanns Lochmüller , Katharine Bushby c a OptumInsight, Stockholm, Sweden b Institute of Envi...
متن کاملThe Sample Complexity of Online One-Class Collaborative Filtering
881 882 883 884 885 886 887 888 889 890 891 892 893 894 895 896 897 898 899 900 901 902 903 904 905 906 907 908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 971 972 973 974 975 976 977 978 979 9...
متن کاملStandards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.
Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 932 Goals and objectives 933 Participants 933 Evidence, methodology and validation 933 Concept of a "live", modular document 933 Organisation of the document 933 De® nition of COPD . . . . . . . . . . . . . . . . . . . . . . . 933 Diagnosis of COPD . . . . . . . . . . . . . . . . . . . . . . . 933 Epidemio ogy, risk factors an...
متن کاملRbCuFe(PO4)2
A new iron phosphate, rubidium copper(II) iron(III) bis-(phosphate), RbCuFe(PO4)2, has been synthesized as single crystals by the flux method. This compound is isostructural with KCuFe(PO4)2 [Badri et al. (2011 ▶), J. Solid State Chem. 184, 937-944]. Its structure is built up from Cu2O8 units of edge-sharing CuO5 polyhedra, inter-connected by FeO6 octa-hedra through common corners to form undul...
متن کاملMohs micrographic surgery vs traditional surgical excision: a cost comparison analysis.
OBJECTIVE To compare the cost and margin adequacy of Mohs micrographic surgery (Mohs) and traditional surgical excision (TSE) for the treatment of facial and auricular nonmelanoma skin cancer (NMSC). DESIGN Prospective cost analysis with each patient serving as his or her own control. SETTING Study was performed from 1999 to 2001 at the University of Connecticut dermatology clinic, a tertia...
متن کامل